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Codeine coupled with an antihistamine, and often caffeine, is marketed less than a variety of trade names and is out there with out a prescription. These products and solutions are held behind the counter and must be dispensed by a pharmacist who may perhaps Restrict portions.[citation necessary]
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Also, no evidence implies that CYP2D6 inhibition is beneficial in managing codeine dependence,[23] although the metabolism of codeine to morphine (and for this reason even further metabolism to glucuronide morphine conjugates) does have an effect on the abuse opportunity of codeine.
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When this medication is utilized for a very long time, it may not operate as well. Talk with your medical doctor if this medication stops Functioning properly.
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Weak proof implies that it's useful in cancer ache, but it surely can have amplified adverse consequences, Primarily constipation, compared to other opioids.